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DedCat
09-21-2007, 10:00 PM
I'm looking for a reliable online source of information about the basic
neurophysiology of psilocybin. i.e. the activational or inhibitory effects
it has on which specific regions of the brain. I'm most interested in which
regions are effected than the actual pharmacological or chemical reasons for
the effect. I've heard that it activates serotonin receptors, but
whereabouts?

If anyone has a link they'd care to share, I'd appreciate it.

Jon Smyth
09-21-2007, 10:00 PM
Try the vaults of Erowid and report back to us what you find.


http://www.erowid.org/



Jon Smyth





DedCat wrote:
> I'm looking for a reliable online source of information about the basic
> neurophysiology of psilocybin. i.e. the activational or inhibitory effects
> it has on which specific regions of the brain. I'm most interested in which
> regions are effected than the actual pharmacological or chemical reasons for
> the effect. I've heard that it activates serotonin receptors, but
> whereabouts?
>
> If anyone has a link they'd care to share, I'd appreciate it.
>
>

no@spamtoday
09-21-2007, 10:00 PM
"DedCat" <deadcat@prontomail.com> wrote:

> I'm most interested in which
> regions are effected than the actual pharmacological or chemical reasons
for
> the effect.

I guess I can lookup the receptor binding affinity of psilocin for the 5HT2A
and the 5HT2C receptors in the brain, which are (if I remeber it correctly)
most abundant in the raphe nuclei in the brain stem. But I wonder if this is
more informative to you than it is for me. (I have no idea how useful that
info is for the understanding of the psilocybian experience).

Yachaj

charlie
09-21-2007, 10:01 PM
"DedCat" <deadcat@prontomail.com> wrote in message
news:dX_Ma.56684$2ay.1672@news01.bloor.is.net.cabl e.rogers.com...
> I'm looking for a reliable online source of information about the basic
> neurophysiology of psilocybin. i.e. the activational or inhibitory
effects
> it has on which specific regions of the brain. I'm most interested in
which
> regions are effected than the actual pharmacological or chemical reasons
for
> the effect. I've heard that it activates serotonin receptors, but
> whereabouts?
>
> If anyone has a link they'd care to share, I'd appreciate it.
>
>
Try http://www.lycaeum.org/ a large entheogenic database which should
answer all your questions

Charlie

Mr Pixie
09-21-2007, 10:02 PM
"charlie" <anon@anon.net> wrote in message
news:ZmXRa.770$xu.221006@newsfep2-gui.server.ntli.net...
>
> "DedCat" <deadcat@prontomail.com> wrote in message
> news:dX_Ma.56684$2ay.1672@news01.bloor.is.net.cabl e.rogers.com...
> > I'm looking for a reliable online source of information about the basic
> > neurophysiology of psilocybin. i.e. the activational or inhibitory
> effects
> > it has on which specific regions of the brain. I'm most interested in
> which
> > regions are effected than the actual pharmacological or chemical reasons
> for
> > the effect. I've heard that it activates serotonin receptors, but
> > whereabouts?
> >
> > If anyone has a link they'd care to share, I'd appreciate it.
> >
> >
> Try http://www.lycaeum.org/ a large entheogenic database which should
> answer all your questions
>
> Charlie
>

I think there is much to be learned from investigating delusional disorders
and schizophrenic patients, because many of these effects may, and do, occur
on a trip.

I saw an interesting program on Discovery a few days ago - they said that
there is not one visual cortex, but about 30 areas of the brain responsible
for visual perception - each with a different 'meaning' attached. I could
theorise that any of these visual areas may be affected during a trip,
giving different effects. For instance on person's disorder was the
inability to name an object correctly upon seeing it - he was also no good
with recognising faces, but as soon as the unrecognised person spoke to him,
all the associated emotions and memories came flooding back and recognition
was achieved - so here we have a case of visual recognition being affected
but rescued by auditory input which was not affected. They could therefore
narrow down the particular brain pathway responsible for the condition and
eliminate other candidate pathways - in this case the affected pathway was
the visual cortex-medulla oblongata pathway, as opposed to the visual
cortex-hypothalamus pathway.

There was also a case of a person who has a delusional state that he thinks
he is God - the same kind of cosmic oneness with the universe that is
experienced on a high dose trip. This was said to be a disorder of the
hypothalamus. This is an interesting one because it suggests that we all
have a brain area devoted to religious experience, which is a bit
controvertial, but may be true.

dave L
09-21-2007, 10:02 PM
i think because it is so similar to seratonin it replaces seratonin as
a neurotransmitter in the brain - like swapping out the lens on a
camera, the light (impulses travelling between neurones) is
transmitted differently ...

Am i just talking out my arse?

dave L

behaves like a repl"Mr Pixie" <nowt@nowt.com> wrote in message news:<bfgbmr$eb7mq$1@ID-103384.news.uni-berlin.de>...
> "charlie" <anon@anon.net> wrote in message
> news:ZmXRa.770$xu.221006@newsfep2-gui.server.ntli.net...
> >
> > "DedCat" <deadcat@prontomail.com> wrote in message
> > news:dX_Ma.56684$2ay.1672@news01.bloor.is.net.cabl e.rogers.com...
> > > I'm looking for a reliable online source of information about the basic
> > > neurophysiology of psilocybin. i.e. the activational or inhibitory
> effects
> > > it has on which specific regions of the brain. I'm most interested in
> which
> > > regions are effected than the actual pharmacological or chemical reasons
> for
> > > the effect. I've heard that it activates serotonin receptors, but
> > > whereabouts?
> > >
> > > If anyone has a link they'd care to share, I'd appreciate it.
> > >
> > >
> > Try http://www.lycaeum.org/ a large entheogenic database which should
> > answer all your questions
> >
> > Charlie
> >
>
> I think there is much to be learned from investigating delusional disorders
> and schizophrenic patients, because many of these effects may, and do, occur
> on a trip.
>
> I saw an interesting program on Discovery a few days ago - they said that
> there is not one visual cortex, but about 30 areas of the brain responsible
> for visual perception - each with a different 'meaning' attached. I could
> theorise that any of these visual areas may be affected during a trip,
> giving different effects. For instance on person's disorder was the
> inability to name an object correctly upon seeing it - he was also no good
> with recognising faces, but as soon as the unrecognised person spoke to him,
> all the associated emotions and memories came flooding back and recognition
> was achieved - so here we have a case of visual recognition being affected
> but rescued by auditory input which was not affected. They could therefore
> narrow down the particular brain pathway responsible for the condition and
> eliminate other candidate pathways - in this case the affected pathway was
> the visual cortex-medulla oblongata pathway, as opposed to the visual
> cortex-hypothalamus pathway.
>
> There was also a case of a person who has a delusional state that he thinks
> he is God - the same kind of cosmic oneness with the universe that is
> experienced on a high dose trip. This was said to be a disorder of the
> hypothalamus. This is an interesting one because it suggests that we all
> have a brain area devoted to religious experience, which is a bit
> controvertial, but may be true.

H.R.M. QUEEN ELIZABETH II
09-21-2007, 10:02 PM
LIBARIES HAVE EMAIL NEWSGROUPS FOR PROFESSIONALS WHO NEED TO UNDERSTAND
CHEMICAL PROCESS, ETC.S:QE2.